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Looking Chloride Channels Straight in the Eye: Bestrophins, Lipofuscinosis, and Retinal Degeneration
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http://physiologyonline.physiology.org/cgi/content/full/20/5/292 |
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| Description | Recent evidence suggests that Cl– ion channels are important for retinal integrity. Because Cl– channels regulate the ionic environment inside organelles in the endosomal-lysosomal pathway, retinal degeneration may result from defects in lysosomal trafficking or function. | |
| Authors |
H. Criss Hartzell, Emory University School of Medicine Zhiqiang Qu, Emory University School of Medicine Ilva Putzier, Emory University School of Medicine Liana Artinian, Emory University School of Medicine Li-Ting Chien, Emory University School of Medicine Yuanyuan Cui, Emory University School of Medicine |
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| Grade/Age Levels |
Undergraduate lower division (Grades 13-14) Undergraduate upper Division (Grades 15-16) Continuing Education Graduate Professional (degree program) |
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| Type of Review | Reviewed By Journal Board | |
| Keywords | Channel, Chloride, Disease, Eye, Human, Retina, Teaching material | |
| Language | English | |
| Disciplines | Cell biology, Human biology, Physiology | |
| Format | Web Page - HTM | |
| Type of Resource | Journal article/issue | |
| Difficulty Level | At grade/age level | |
| Learning Time | <=1 hour | |
| Pedagogy | Teacher-centered/traditional instruction | |
| APS/ACDP Medical Objective in Physiology |
Visual system | |
| Related Research Papers |
http://ajpcell.physiology.org/cgi/content/abstract/262/2/C374 http://ajpcell.physiology.org/cgi/content/abstract/265/4/C1037 http://ajpcell.physiology.org/cgi/content/abstract/266/3/C676 http://physrev.physiology.org/cgi/content/abstract/82/2/503 http://physrev.physiology.org/cgi/content/abstract/85/3/845 |
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